Serum ferritin as a significant biomarker for patients with idiopathic inflammatory myopathy-associated interstitial lung disease: A systematic review and meta-analysis
Pooled result · SF levels, IIM-ILD vs IIM without ILDResult — go to the resultWMD 263.53 ng/mL 95% CI 146.44–380.62Authors' conclusion
Increased SF levels can serve as a biomarker for predicting the occurrence, progression and death of patients with IIM-ILD
Study context
- Population
- Patients with IIM (studies from PubMed, Embase, Web of science and Scopus up to 9 June 2023)
- Participants
- 1,933 patients19 studies
- Comparison
- Serum ferritin (SF) levels in IIM-ILD vs IIM without ILD; RP-ILD vs chronic ILD (C-ILD); death vs survival
- Outcome
- SF levels (WMD) in IIM-ILD vs IIM without ILD
Methodological detailssubgroup analysis by disease type, sensitivity analysis, Egger's test
- Subgroup analysis by disease type
- Sensitivity analysis
- Egger's test
Pooled result
SF levels, IIM-ILD vs IIM without ILD
WMD
263.53 ng/mL
95% CI 146.44–380.62
P < 0.001
IIM-ILDvs IIM without ILD
WMD 263.53 ng/mL (95% CI 146.44–380.62); P < 0.001
As reported in the abstract
Further pooled results
| Outcome | WMD (ng/mL) (95% CI) | P value | |
|---|---|---|---|
| SF levels with vs without ILD by disease type (subgroup)DM-ILDvs DM without ILD | 397.67 (142.84–652.50) | P = 0.002 | |
| SF levels with vs without ILD by disease type (subgroup)PM/DM-ILDvs PM/DM without ILD | 117.68 (86.32–149.04) | P < 0.001 | |
| SF levels, RP-ILD vs C-ILDRP-ILDvs C-ILD | 484.99 (211.12–758.87) | P = 0.001 | |
| SF levels, RP-ILD vs C-ILDDM-RP-ILDvs DM-C-ILDSubgroup | 509.75 (215.34–804.16) | P = 0.001 | |
| SF levels, death vs survivalDeathvs Survival | 722.16 (572.32–872.00) | P < 0.001 | |
| SF levels, death vs survivalDeath (DM-ILD)vs Survival (DM-ILD)Subgroup | 735.62 (574.92–896.32) | P < 0.001 | |
| SF levels, death vs survivalDeath (PM-ILD)vs Survival (PM-ILD)Subgroup | 632.56 (217.92–1047.19) | P = 0.003 | |
| −500050010001500Difference, ng/mL (linear scale) |
Original publication
Serum ferritin as a significant biomarker for patients with idiopathic inflammatory myopathy-associated interstitial lung disease: A systematic review and meta-analysis. Semin Arthritis Rheum. Published 10 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →