Cardiovascular risk in myositis patients compared with the general population
Authors' conclusion
Significantly higher prevalence of traditional risk factors and subclinical atherosclerosis was observed in IIM patients compared with HC.
Study context
- Population
- Idiopathic inflammatory myopathies (IIM) patients and age-/sex-matched healthy controls (HC) without a history of cardiovascular (CV) disease (angina pectoris, MI, cerebrovascular/peripheral arterial vascular events)
- Participants
- 90 vs 180
- Comparison
- IIM vs age-/sex-matched HC
- IIMn = 90
- HCn = 180reference
- Outcome
- CV risk: CIMT, PWV, ABI, body composition, and risk of fatal CV events by SCORE and its modifications
Methodological detailsage-/sex-matched, propensity score matching
- Age-/sex-matched
- Propensity score matching
Main finding
As reported in the abstract
- Significantly higher prevalence of traditional CV risk factors, carotid artery disease (CARD), abnormal ankle-brachial index (ABI) and pulse wave velocity (PWV) in IIM vs HC
- After propensity score matching, prevalence of CARD and pathological PWV remained significantly higher in IIM than HC
- No significant difference in Systematic COronary Risk Evaluation (SCORE)
Observational data: associations, not effects.
Further findings
CV risk by IIM subtype
- Most unfavourable CV risk profile in necrotizing myopathy, especially statin-induced anti-HMGCR+ patients
Accuracy of CV risk scores (SCORE, SCORE2, mSCORE) reclassified by carotid intima-media thickness (CIMT) and carotid plaques
- SCORE most inaccurate in predicting CV risk in IIM
Predictors of CV risk in IIM
- Age, disease activity, lipid profile, body composition parameters and blood pressure were the most significant predictors
Original publication
Cardiovascular risk in myositis patients compared with the general population. Rheumatology (Oxford). Published 5 June 2023. doi:10.
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