Clinical, radiological and pathological features of anti-MDA5 antibody-associated interstitial lung disease
Authors' conclusion
RPILD was commonly observed in patients with anti-MDA5+DM. OP was identified as the predominant radiographic pattern, which corresponded to a histopathological pattern of NSIP or NSIP+OP. Notably, patients exhibiting radiographic patterns of NSIP+OP or DAD were shown to have a poor prognosis.
Study context
- Population
- Patients with anti-MDA5+DM who had undergone radiological examinationhistopathology in 17
- Participants
- 329 patients
- Exposure
- Rapidly progressive ILD (RPILD) vs without RPILD
- RPILDn = 177
- Outcome
- ILD features in anti-MDA5+DM
Methodological detailsretrospective medical records review
- Retrospective medical records review
Main finding
As reported in the abstract
- Interstitial lung disease (ILD)
- 308 (93.6%)
- RPILD
- 177 (53.8%)
- Radiographic organising pneumonia (OP) pattern
- 43.2%
- Radiographic non-specific interstitial pneumonia (NSIP) pattern
- 26.4%
- Radiographic NSIP+OP pattern
- 18.5%
- Histological NSIP pattern
- 41.2%
- Histological NSIP+OP pattern
- 47.1%
- Radiological–histopathological coincidence rate (17 with histopathology)
- 11.8%
Observational data: associations, not effects.
Further findings
NSIP+OP pattern on high-resolution CT
P = 0.001
NSIP pattern on high-resolution CT
P = 0.002
12-month mortality by radiographic pattern
- NSIP+OP pattern
- 45.9%
- Diffuse alveolar damage (DAD) pattern
- 100%
- More risk factors for poor prognosis
Original publication
Clinical, radiological and pathological features of anti-MDA5 antibody-associated interstitial lung disease. RMD Open. Published 31 May 2023. doi:10.
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