A Systematic Review and Metaanalysis of Predictors of Mortality in Idiopathic Inflammatory Myopathy–Associated Interstitial Lung Disease
Authors' conclusion
Many mortality risk factors were identified, though heterogeneity was high, with a low quality of evidence and a risk of publication bias.
Study context
- Population
- Patients with concurrent idiopathic inflammatory myopathy (IIM) and interstitial lung disease (ILD); MEDLINE and Embase searched to October 18, 202162 papers
- Comparison
- Baseline immunological, clinical and radiographical characteristics as predictors of mortality
- Outcome
- Mortality
Methodological detailsrandom-effects model, Newcastle-Ottawa Scale risk of bias, Egger test for publication bias
- Random-effects model
- Newcastle-Ottawa Scale risk of bias
- Egger test for publication bias
Pooled result
As reported in the abstract
Anti-MDA5 antibodies, OR for death
6.20
95% CI 3.58–10.71
Anti-tRNA synthetase antibodies, protective, OR
0.24
95% CI 0.14–0.41
Original publication
A Systematic Review and Metaanalysis of Predictors of Mortality in Idiopathic Inflammatory Myopathy–Associated Interstitial Lung Disease. J Rheumatol. Published 1 September 2022. doi:10.
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