Adverse Pregnancy Outcomes in Adult Patients With Idiopathic Inflammatory Myopathy: A Systematic Review and Meta‐Analysis
Authors' conclusion
Our meta-analysis showed IIM to be associated with increased risk of hypertensive disorders of pregnancy, cesarean section, preterm birth, and infants who are small for gestational age or had intrauterine growth restriction, although residual confounding by disease activity and treatment may contribute.
Study context
- Population
- Pregnant adult patients with IIM (predominantly DM or PM) and pregnant patients without IIM; databases searched to May 15, 20255 population-based retrospective cohorts
- Comparison
- Pregnant patients with IIM vs pregnant patients without IIM
- Outcome
- Adverse pregnancy outcomes
Methodological detailspopulation-based retrospective cohorts, random-effects model with inverse-variance weighting, Newcastle-Ottawa Scale quality assessment
- Population-based retrospective cohorts
- Random-effects model with inverse-variance weighting
- Newcastle-Ottawa Scale quality assessment
Pooled result
As reported in the abstract
Adverse pregnancy outcomes, pooled OR
IIM vs Without IIMOdds ratio (95% CI)P value
Hypertensive disorders of pregnancy; I2 = 70%, Cochran's Q P = 0.01
2.73(1.76–4.23)
overall effect P < 0.00001Cesarean section; I2 = 79%, Cochran's Q P = 0.002
2.03(1.37–3.00)
overall effect P = 0.004Preterm birth; I2 = 60%, Cochran's Q P = 0.06
3.71(2.35–5.85)
overall effect P < 0.00001Small for gestational age or intrauterine growth restriction; I2 = 43%, Cochran's Q P = 0.15
1.90(1.03–3.51)
overall effect P = 0.04Original publication
Adverse Pregnancy Outcomes in Adult Patients With Idiopathic Inflammatory Myopathy: A Systematic Review and Meta‐Analysis. Arthritis Care Res (Hoboken). Published 21 April 2026. doi:10.
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