Evaluation of the prognostic value of visual and quantitative CT analysis in myositis-associated interstitial lung disease
Authors' conclusion
In this large, real-world IIM cohort, quantitative HRCT measures-particularly QLF and QILD-were strongly associated with lung function and predicted mortality.
Study context
- Population
- Patients with idiopathic inflammatory myositis (IIM) in a single-centre longitudinal cohort (mean age 51 years; 74% female; 77% DM; 22% ASyS)168 with evaluable high-resolution CT (HRCT)
- Participants
- 277 patients
- Outcome
- All-cause mortality associated with quantitative imaging analysis (QIA) measures (QLF, QILD) and visual ILD assessment
Methodological detailssingle-centre, longitudinal, Cox regression, mixed-effects models
- Single-centre
- Longitudinal
- Cox regression
- Mixed-effects models
Main finding
As reported in the abstract
Higher baseline QLF score, HR (95% CI 1.00 to 1.08); p<0.05 for all
1.04
Higher baseline QILD score, HR (95% CI 1.01 to 1.16); p<0.05 for all
1.08
Worsening QLF trend in first 12 months, HR (95% CI 1.01 to 1.07); p<0.05 for all
1.04
Worsening QILD trend in first 12 months, HR (95% CI 1.01 to 1.11); p<0.05 for all
1.06
Observational data: associations, not effects.
Further findings
ILD on visual review
- ILD identified by visual review
- 51%
Correlation of QLF and QILD with pulmonary function tests (PFTs) across all visits
- QLF vs FVC, β
- −0.7
- QILD vs FVC, β
- −0.59
- QLF vs DLCO, β
- −0.75
- QILD vs DLCO, β
- −0.64
- P for all
- P < 0.0001
Original publication
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