Intramuscular lesions in musculoskeletal MRI as a favourable prognostic sign in patients with anti-MDA5 antibody-positive dermatomyositis
Authors' conclusion
The detection of intramuscular lesions on musculoskeletal MRI using our novel evaluation method could be clinically useful as a favourable prognostic marker.
Study context
- Population
- Patients with anti-MDA5 antibody-positive DM with proximal-muscle MRI at diagnosis, Jikei University Hospital and Jikei University Kashiwa Hospital, January 2008–March 2022
- Participants
- 28 patients
- Exposure
- Radiological myositis vs no radiological myositis
- Radiological myositisn = 15
- Outcome
- Survival (ILD prognosis) by MRI findings
Methodological detailstwo-centre, MRI read by three observers with consensus
- Two-centre
- MRI read by three observers with consensus
Main finding
As reported in the abstract
Survival
- Patients with radiological myositis had significantly higher survival rates than those without, despite a lower rate of triple therapy (prednisolone, calcineurin inhibitors and CYC)
Observational data: associations, not effects.
Further findings
Spread of interstitial lung disease (ILD) on chest CT vs proportion of intramuscular lesions
- Significant negative correlation
Original publication
Intramuscular lesions in musculoskeletal MRI as a favourable prognostic sign in patients with anti-MDA5 antibody-positive dermatomyositis. RMD Open. Published 28 August 2023. doi:10.
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