Risk prediction modelling in idiopathic inflammatory myositis-associated interstitial lung disease based on seven factors including serum KL-6 and lung ultrasound B-lines
Authors' conclusion
This predictive model demonstrates robust capability to assess ILD risk in IIM patients, particularly when augmented with serum KL-6 level or/and LUS B-line number.
Study context
- Population
- Idiopathic inflammatory myositis (IIM) patients diagnosed January 2013–December 2022, Shantou Central Hospital115 (56.1%) with interstitial lung disease (ILD)
- Participants
- 205 patients
- Exposure
- 5-factor model vs 5 factors + KL-6 vs 5 factors + B-line number vs 5 factors + KL-6 + B-line number
- Outcome
- Prediction of ILD in IIM (AUC of ROC)
Methodological detailssingle-centre, LASSO regression, nomogram-based predictive model, training and validation sets
- Single-centre
- LASSO regression
- Nomogram-based predictive model
- Training and validation sets
Main finding
As reported in the abstract
AUC of ROC for ILD prediction
| Group | AUC (training set) | AUC (validation set) | AUC |
|---|---|---|---|
| 5-factor model | 0.876 | 0.861 | — not stated in the abstract |
| 5 factors + KL-6 | — not stated in the abstract | — not stated in the abstract | 0.922 |
| 5 factors + B-line number | — not stated in the abstract | — not stated in the abstract | 0.949 |
| 5 factors + KL-6 + B-line number | — not stated in the abstract | — not stated in the abstract | 0.951 |
AUC (training set)
5-factor model0.876
5 factors + KL-6— not stated in the abstract
5 factors + B-line number— not stated in the abstract
5 factors + KL-6 + B-line number— not stated in the abstract
AUC (validation set)
5-factor model0.861
5 factors + KL-6— not stated in the abstract
5 factors + B-line number— not stated in the abstract
5 factors + KL-6 + B-line number— not stated in the abstract
AUC
5-factor model— not stated in the abstract
5 factors + KL-60.922
5 factors + B-line number0.949
5 factors + KL-6 + B-line number0.951
— not stated in the abstract
Observational data: associations, not effects.
Original publication
Risk prediction modelling in idiopathic inflammatory myositis-associated interstitial lung disease based on seven factors including serum KL-6 and lung ultrasound B-lines. Clin Exp Rheumatol. Published 14 May 2024. doi:10.
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