Combination of cytoplasmic and nuclear patterns on Hep-2 antinuclear antibody is useful as a screening test for anti-synthetase syndrome
Authors' conclusion
It is important to detect cytoplasmic patterns as an ANA screening test for ASS diagnosis, even if the titre is low. Additionally, combining the cytoplasmic and ncANA patterns yields more accurate ASS screening results.
Study context
- Population
- Patients with ANA-associated rheumatic diseases (AARDs) (SLE, SSc, SS, MCTD, PM/DM) who underwent ANA screening, April 2012–December 2021
- Participants
- 64 / 451 / 264 / 201 / 104 / 52
- Exposure
- Anti-synthetase syndrome (ASS) vs other ANA-associated rheumatic diseases, by combination of cytoplasmic and ncANA patterns on Hep-2 ANA
- ASSn = 64
- SSn = 451
- SScn = 264
- SLEn = 201
- PM/DMn = 104
- MCTDn = 52
- Outcome
- Differentiation of ASS from other AARDs by combined cytoplasmic and ncANA patterns
Methodological detailsretrospective observational, logistic regression, ROC analysis
- Retrospective observational
- Logistic regression
- ROC analysis
Main finding
As reported in the abstract
Discrimination of ASS from other AARDs by cytoplasmic and ncANA range
AUC (ROC)
0.885
95% CI 0.844–0.927
Observational data: associations, not effects.
Further findings
- No overlap between AARDs and ASS
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Combination of cytoplasmic and nuclear patterns on Hep-2 antinuclear antibody is useful as a screening test for anti-synthetase syndrome. Rheumatology (Oxford). Published 2 May 2024. doi:10.
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