Clinical-imaging characteristics and management of anti-JO-1 and non-JO-1 anti-synthetase syndrome–associated interstitial lung disease
Authors' conclusion
Patients with ASS-ILD had distinctive clinical-imaging characteristics associated with different antibodies, and non-anti-Jo-1 patients were susceptible to presenting a fibrotic phenotype.
Study context
- Population
- Patients diagnosed with anti-synthetase syndrome-associated ILD (ASS-ILD) from two centres
- Participants
- 377 patients
- Exposure
- Anti-Jo-1 vs non-Jo-1 ASS-ILD
- Anti-Jo-1n = 169
- Non-Jo-1n = 208
- Outcome
- Clinical-radiographic characteristics by antibody subgroup
Methodological detailstwo centres
- Two centres
Main finding
As reported in the abstract
- Non-Jo-1 had longer diagnostic periods vs anti-Jo-1
- P = 0.037
- Non-Jo-1 had more hyperglobulinemia vs anti-Jo-1
- P < 0.05
- Non-Jo-1 ASS-ILD more frequently combined with secondary SS vs anti-Jo-1
- P = 0.003
- Organizing pneumonia pattern on high-resolution CT (HRCT), anti-Jo-1
- 15.6%
- Usual interstitial pneumonia (UIP) pattern, non-Jo-1
- 43.3%
- Non-specific interstitial pneumonia (NSIP) pattern, non-Jo-1
- 52.2%
Observational data: associations, not effects.
Original publication
Clinical-imaging characteristics and management of anti-JO-1 and non-JO-1 anti-synthetase syndrome–associated interstitial lung disease. Rheumatology (Oxford). Published 27 May 2025. doi:10.
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