Statin-associated immune-mediated necrotizing myopathy in Hispanic Americans
Main finding · Statin-induced anti-HMGCR antibody IMNMResult — go to the resultOdds ratio 4.81 CI 1.03–22.6Authors' conclusion
Hispanics in the Southwestern USA have increased statin-induced anti-HMGCR antibody IMNM and a lesser prevalence of cancer-associated IIM compared to non-Hispanics.
Study context
- Population
- Adults with Idiopathic Inflammatory Myopathies (IIM), Hispanic and non-Hispanic Caucasians in the Southwestern USA
- Participants
- 97 adults
- Exposure
- Hispanic vs non-Hispanic Caucasian adults with IIM
- Hispanicn = 62
- Non-Hispanicn = 35reference
- Outcome
- Statin-induced anti-HMGCR antibody immune-mediated necrotizing myopathy (IMNM)
Main finding
As reported in the abstract
Odds ratio
4.81
CI 1.03–22.6
P = 0.045
By group
Hispanicvs Non-Hispanic
OR 4.81 (CI 1.03–22.6); P = 0.045
Observational data: associations, not effects.
Further findings
%
| Outcome | Hispanic | Non-Hispanic | OR (CI) | P value | |
|---|---|---|---|---|---|
| Diabetes mellitus | 46.8 | 25.7 | 2.54 (1.02–6.29) | P = 0.05 | |
| Cancer-associated IIM | 11.3 | 31.4 | 0.23 (0.08–0.7) | P = 0.027 | |
| 0.050.21520Odds ratio (log scale) |
Baseline characteristics, autoantibody profiles, clinical outcomes and mortality
- The two groups were similar
Original publication
Statin-associated immune-mediated necrotizing myopathy in Hispanic Americans. Semin Arthritis Rheum. Published 24 May 2025. doi:10.
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