Increased prevalence and incidence of statin-associated immune-mediated necrotizing myopathy in Native Americans
Authors' conclusion
Statin-associated IMNM is significantly more common in Native Americans in the American Southwest. The treatments received and outcomes of statin-associated IMNM in Native Americans and non-NA seem to be similar.
Study context
- Population
- Subjects with idiopathic inflammatory myopathy (IIM) (standard criteria) from the American Southwest; statin-associated immune-mediated necrotizing myopathy (IMNM) required anti-HMGCR antibodiessubjects with IIM
- Participants
- 148 subjects
- Exposure
- Native Americans vs non-Native Americans with IIM
- Native Americansn = 33
- non-NAn = 115reference
- Outcome
- Proportion of IIM and IMNM, clinical and laboratory parameters, and outcomes
Methodological detailssingle-institution
- Single-institution
Main finding
As reported in the abstract
Estimated prevalence and incidence of statin-associated IMNM
| Group | Value | Incidence |
|---|---|---|
| Native Americans | 182 cases/106 population | 66.4 cases/year/106 population |
| non-NA | 30.6 cases/106 population | 7.5 cases/year/106 population |
Value
Native Americans182 cases/106 population
non-NA30.6 cases/106 population
Incidence
Native Americans66.4 cases/year/106 population
non-NA7.5 cases/year/106 population
Observational data: associations, not effects.
Further findings
Hyperlipidemia
P = 0.015
Statin exposure
P = 0.002
Diabetes mellitus
P = 0.044
Esophageal dysmotility
P = 0.042
Anti-RNP antibody
P = 0.013
Anti-HMGCR antibody
P = 0.0007
BMI, myositis damage index, inflammatory arthritis
- Lower in Native Americans than non-NA
Clinical outcomes and treatment received
- No significant differences between the two groups
Original publication
Increased prevalence and incidence of statin-associated immune-mediated necrotizing myopathy in Native Americans. Rheumatology (Oxford). Published 21 November 2025. doi:10.
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