Assessment of anti-malondialdehyde-acetaldehyde antibody frequencies in rheumatoid arthritis with new data from two independent cohorts, meta-analysis, and meta-regression
Authors' conclusion
Anti-MAA antibody sensitivity is extremely variable between RA patient collections. A substantial fraction of this variability cannot be attributed to ELISA protocols. On the contrary, heterogeneity is determined by complex factors that include African ethnicity, smoking, and sex.
Study context
- Population
- RA patients and healthy controls from Santiago and Barcelona; plus published reports of anti-malondialdehyde-acetaldehyde (anti-MAA) antibodies in RA (Web of Science)11 sets in meta-analysis
- Participants
- 4,989 patients
- Comparison
- Santiago RA vs Barcelona RA vs Santiago controls vs Barcelona controls
- Santiago RAn = 517
- Barcelona RAn = 178
- Santiago controlsn = 272reference
- Barcelona controlsn = 120reference
- Outcome
- Sensitivity (frequency of positives) of anti-MAA antibodies in RA and between-study heterogeneity
Methodological detailstwo independent cohorts (Santiago and Barcelona), replication study, ELISA with five antigens and IgG, IgM and IgA isotypes
- Two independent cohorts (Santiago and Barcelona)
- Replication study
- ELISA with five antigens and IgG, IgM and IgA isotypes
Pooled result
As reported in the abstract
Sensitivity of anti-MAA antibodies in own RA patients
Low sensitivity, even in seropositive patients; positives below 23% for all ELISA conditions
<23%
IgG anti-MAA positive patients across own results and literature
6 to 92%
Further pooled results
Between-study heterogeneity explained (meta-regression)
- Univariate: sex, African ethnicity, site of study or military recruitment explained up to
- 43%
- Best model (African ancestry and smoking) explained
- 74%
Original publication
Assessment of anti-malondialdehyde-acetaldehyde antibody frequencies in rheumatoid arthritis with new data from two independent cohorts, meta-analysis, and meta-regression. Arthritis Res Ther. Published 5 October 2023. doi:10.
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