Antibodies to Malondialdehyde‐Acetaldehyde Adduct Are Associated With Prevalent and Incident Rheumatoid Arthritis–Associated Interstitial Lung Disease in US Veterans
Authors' conclusion
Protein-specific anti-MAA antibodies to collagen, fibrinogen, and vimentin were associated with prevalent RA-ILD. IgA and IgM anti-MAA-albumin antibodies were associated with a higher risk of incident RA-ILD.
Study context
- Population
- US veterans with RA in a multicenter prospective cohort (88% male, mean age 64 years)114 prevalent, 136 incident rheumatoid arthritis-interstitial lung disease (RA-ILD)
- Participants
- 2,739 veterans
- Exposure
- Higher vs lower serum anti-MAA antibody concentrations
- Outcome
- Associations of protein-specific anti-MAA antibodies (MAA-albumin, -collagen, -fibrinogen, -vimentin; IgA, IgM, IgG) with prevalent and incident RA-ILD
Methodological detailsmulticenter, multivariable regression adjusting for established RA-ILD risk factors, Serum anti-MAA antibodies measured by standardized ELISA, RA-ILD validated by medical record review of clinical diagnoses, chest imaging and pathology
- Multicenter
- Multivariable regression adjusting for established RA-ILD risk factors
- Serum anti-MAA antibodies measured by standardized ELISA
- RA-ILD validated by medical record review of clinical diagnoses, chest imaging and pathology
Main finding
As reported in the abstract
- Prevalent RA-ILD, IgM anti-MAA-collagen, aOR per 1 SD
- 1.28 (95% CI 1.02-1.61)
- Prevalent RA-ILD, IgA anti-MAA-fibrinogen, aOR
- 1.48 (95% CI 1.14-1.92)
- Prevalent RA-ILD, IgA anti-MAA-vimentin, aOR
- 1.78 (95% CI 1.34-2.37)
- Prevalent RA-ILD, IgG anti-MAA-vimentin, aOR
- 1.48 (95% CI 1.14-1.92)
- Incident RA-ILD, IgA anti-MAA-albumin, aHR per 1 SD
- 1.40 (95% CI 1.11-1.76)
- Incident RA-ILD, IgM anti-MAA-albumin, aHR per 1 SD
- 1.29 (95% CI 1.04-1.60)
Observational data: associations, not effects.
Further findings
Incident RA-ILD, anti-MAA-albumin in highest quartile
- IgA anti-MAA-albumin highest quartile, aHR
- 2.13 (95% CI 1.16-3.90)
- IgM anti-MAA-albumin highest quartile, aHR
- 1.98 (95% CI 1.08-3.64)
- Approximately two-fold increased risk
Original publication
Antibodies to Malondialdehyde‐Acetaldehyde Adduct Are Associated With Prevalent and Incident Rheumatoid Arthritis–Associated Interstitial Lung Disease in US Veterans. Arthritis Rheumatol. Published 8 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →