Combining Three Peripheral Blood Biomarkers to Stratify Rheumatoid Arthritis–Associated Interstitial Lung Disease Risk
Main finding · Prevalent RA-ILDResult — go to the resultAdjusted odds ratio 12.21 95% CI 3.82–38.97Authors' conclusion
This three-analyte biomarker score was associated with both prevalent and incident RA-ILD, improving risk stratification beyond clinical risk factors.
Study context
- Population
- Multicentre cohort of US veterans with rheumatoid arthritis (RA); Interstitial lung disease (ILD) confirmed by chest imaging or lung biopsy pathology reports88 prevalent RA-ILD
- Participants
- 2,043 participants
- Exposure
- Combined three-biomarker score: score 3 vs 0
- Outcome
- Prevalent RA-ILD (cross-sectional) and incident RA-ILD (cohort)
Methodological detailsmulticentre, multivariate logistic and Cox regression adjusted for clinical risk factors
- Multicentre
- Multivariate logistic and Cox regression adjusted for clinical risk factors
Main finding
Prevalent RA-ILD
Adjusted odds ratio
12.21
95% CI 3.82–38.97
Score 3vs Score 0
aOR 12.21 (95% CI 3.82–38.97)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Incident RA-ILD (148 participants)Highest risk | 4.36 (1.55–12.27) | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Diagnostic performance for prevalent RA-ILD, score ≥1
- Sensitivity
- 76.1%
- Specificity
- 48.6%
AUC (prevalent) and Harrell's C (incident)
- Highest when clinical risk factors combined with biomarker score
Original publication
Combining Three Peripheral Blood Biomarkers to Stratify Rheumatoid Arthritis–Associated Interstitial Lung Disease Risk. Arthritis Care Res (Hoboken). Published 24 February 2026. doi:10.
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