Rheumatoid arthritis

Exposure to Occupational Inhalants and the Risk of Developing Rheumatoid Arthritis: A Systematic Review and Meta‐Analysis

Arthritis RheumatolPublished Systematic review and meta-analysis

Authors' conclusion

Occupational inhalants are associated with increased RA risk

Study context

Population
Population-based cross-sectional, case-control and cohort studies of occupational inhalant exposures and rheumatoid arthritis (RA); MEDLINE, Embase, Web of Science to November 20, 202431 studies
Comparison
Exposure to occupational inhalants vs no exposure
Outcome
Risk of developing RA
Methodological detailsPRISMA, random-effects meta-analyses, Newcastle-Ottawa Scale risk-of-bias assessment
  • PRISMA
  • Random-effects meta-analyses
  • Newcastle-Ottawa Scale risk-of-bias assessment

Pooled result

As reported in the abstract

RA risk by occupational inhalant (10 types)

Significant associations with RA risk for silica, asbestos, solvents, pesticides, fertilizers, animal dust and engine exhaust (RR range)

1.25 to 1.49

Further pooled results

Moderate-to-high heterogeneity in seven meta-analyses
7

Original publication

Exposure to Occupational Inhalants and the Risk of Developing Rheumatoid Arthritis: A Systematic Review and Meta‐Analysis. Arthritis Rheumatol. Published 2 February 2026. doi:10.1002/art.43446

Composed by AI from the published abstract and checked against it. How Briefs are made →

Get them every week

New studies on this topic in My Week and in your Monday e-mail.

We e-mail you a sign-in link and a code. No password, no spam.