Multibiomarker disease activity score: an objective tool for monitoring rheumatoid arthritis? A systematic review and meta-analysis
Authors' conclusion
The MBDA score might be used as an objective disease activity marker. In addition, it is also a reliable prognostic marker of radiographic progression.
Study context
- Population
- Original articles on the multibiomarker disease activity (MBDA) score in RA; MEDLINE, CENTRAL, Embase, Scopus and Web of Science from inception to 13 October 202132 eligible studies
- Comparison
- MBDA score vs conventional disease activity measures; high (>44) vs low (<30) baseline MBDA score for radiographic progression
- Outcome
- Correlation of MBDA score with conventional disease activity measures
- Follow-up
- Baseline
Pooled result
As reported in the abstract
Correlation (COR) with DAS with CRP (DAS28-CRP) (CI 0.28, 0.59), I2 = 71.0%
0.45
COR with DAS28-ESR (CI 0.19, 0.78), I2 = 0.0%
0.55
COR with DAS28-CRP at follow-up (CI 0.28, 0.57), I2 = 70.0%
0.44
Further pooled results
| Outcome | OR (CI) | |
|---|---|---|
| Radiographic progressionI2 = 10.0%; significantly higher odds | 1.03 (1.02–1.05) | |
| 0.512Odds ratio (log scale) |
Original publication
Multibiomarker disease activity score: an objective tool for monitoring rheumatoid arthritis? A systematic review and meta-analysis. Rheumatology (Oxford). Published 28 December 2022. doi:10.
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