Trends of disease activity in Japanese patients over 75 years with rheumatoid arthritis from 2014 to 2021: the ANSWER cohort study
Authors' conclusion
In our cohort, disease activity among very elderly RA patients has improved over time.
Study context
- Population
- Very elderly RA patients (>75 years) in a multicentre registry in Japan (ANSWER cohort), 2014–202132,161 patient visits
- Exposure
- Trends 2014 to 2021
- Outcome
- Changes in the proportion of very elderly RA patients (>75 years) achieving remission and LDA
- Follow-up
- 2014 to 2021
Methodological detailsmulticentre, multivariate logistic regression
- Multicentre
- Multivariate logistic regression
Main finding
As reported in the abstract
Proportion of RA patients >75 years achieving remission and LDA
- Remission and low disease activity (LDA), 2014
- 62.2%
- Remission and LDA, 2021
- 78.2%
- Significant increase over time
- P for trend < 0.001
Observational data: associations, not effects.
Secondary outcomes
Factors associated with remission and LDA (multivariate logistic regression)
- Negatively associated: GC use, seropositivity, previous b/tsDMARD use
- Positively associated: MTX use, independent of other predictors
Proportion of patients >75 years · 2014 to 2021
- Increase from 2014 to 2021
- 16.5% to 26.9%
- b/tsDMARD use increased, GC use decreased, csDMARD use relatively stable
Original publication
Trends of disease activity in Japanese patients over 75 years with rheumatoid arthritis from 2014 to 2021: the ANSWER cohort study. Rheumatology (Oxford). Published 4 October 2023. doi:10.
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