Pre-pregnancy gene expression signatures are associated with subsequent improvement/worsening of rheumatoid arthritis during pregnancy
Authors' conclusion
The pre-pregnancy gene expression signatures identified represent potential biomarkers to predict the subsequent improvement/worsening of RA during pregnancy
Study context
- Population
- Women with rheumatoid arthritis (RA) and healthy women in a prospective pregnancy cohort with pre-pregnancy baseline blood samples19 RA, 13 healthy
- Participants
- 14 / 5 / 13
- Exposure
- RA improved vs RA worsened during pregnancy
- RAimprovedn = 14
- RAworsenedn = 5
- Healthy womenn = 13reference
- Outcome
- Pre-pregnancy co-expression modules correlated with improvement/worsening of RA (change in CDAI) during pregnancy
- Follow-up
- T0 to 3rd trimester
Methodological detailspre-pregnancy baseline, RNA sequencing, weighted gene co-expression network analysis
- Pre-pregnancy baseline
- RNA sequencing
- Weighted gene co-expression network analysis
Main finding
As reported in the abstract
Pre-pregnancy gene expression signatures · T0 (pre-pregnancy)
- One B cell function-related co-expression module significantly correlated with worsening of RA during pregnancy and significantly enriched in genes differentially expressed between RAimproved and RAworsened
- Neutrophil-related expression signature identified in RAimproved at T0
Observational data: associations, not effects.
Further findings
Mean Clinical Disease Activity Index (CDAI) at T0
- Similar between RAimproved and RAworsened
Original publication
Pre-pregnancy gene expression signatures are associated with subsequent improvement/worsening of rheumatoid arthritis during pregnancy. Arthritis Res Ther. Published 4 October 2023. doi:10.
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