Unique transcriptomic profile of peripheral blood monocytes in rheumatoid arthritis-associated interstitial lung disease
Authors' conclusion
Circulating monocytes in RA-ILD patients demonstrate unique gene expression profiles, with innate immune gene features more aligned with IPF as opposed to RA in the absence of clinical lung disease, and with fibrosis gene expression that was distinct from RA and IPF.
Study context
- Population
- Patients with RA-ILD, rheumatoid arthritis (RA) without lung disease, idiopathic pulmonary fibrosis (IPF), and controls without lung and autoimmune disease; peripheral blood CD14+ monocytes
- Participants
- 5 / 5 / 5 / 4
- Comparison
- Circulating CD14+ monocyte gene expression in RA-ILD vs RA without lung disease, IPF and controls
- RA-ILDn = 5
- RAn = 5
- IPFn = 5
- Controlsn = 4reference
- Outcome
- Gene expression profiles of circulating CD14+ monocytes
Methodological detailstranscriptional analysis of 1365 genes, gene enrichment and pathway analyses
- Transcriptional analysis of 1365 genes
- Gene enrichment and pathway analyses
Main finding
As reported in the abstract
Monocyte gene expression profiles
| Group | Upregulated genes vs controls | Downregulated genes vs controls |
|---|---|---|
| RA-ILD | 103 | 66 |
| RA | 66 | 14 |
| IPF | 64 | 25 |
Upregulated genes vs controls
RA-ILD103
RA66
IPF64
Downregulated genes vs controls
RA-ILD66
RA14
IPF25
Original publication
Unique transcriptomic profile of peripheral blood monocytes in rheumatoid arthritis-associated interstitial lung disease. Rheumatology (Oxford). Published 16 October 2024. doi:10.
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