Trends in Anxiety and Depression Among Individuals With Rheumatoid Arthritis: A Population-Based Study
Authors' conclusion
Anxiety and concomitant anxiety and depression diagnoses are elevated in individuals with RA.
Study context
- Population
- Rochester Epidemiology Project, incident rheumatoid arthritis (RA) 1985–2014 and matched non-RA comparators (mean age 55.9 years, 68.38% female), followed until death, migration or December 31, 2020
- Participants
- 1,012 vs 1,012
- Exposure
- Incident RA vs matched non-RA comparators, by decade
- RAn = 1,012
- Matched controlsn = 1,012reference
- Outcome
- Trends in occurrence of depression, anxiety and cooccurring anxiety and depression diagnoses (ICD-9/10 code sets) by decade and RA status
Methodological detailsmatched 1:1 on age, sex and calendar year of RA incidence, Cox models adjusted for potential confounders
- Matched 1:1 on age, sex and calendar year of RA incidence
- Cox models adjusted for potential confounders
Main finding
As reported in the abstract
Occurrence of anxiety and concomitant anxiety and depression, RA vs controls
RA vs Matched controlsHazard ratio (95% CI)
Anxiety
1.27(0.86–1.88)
Concomitant anxiety and depression
1.49(0.96–2.33)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Anxiety in seropositive RA (subgroup)Seropositive patients with RA | 4.01 (2.21–7.30) | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Trends in Anxiety and Depression Among Individuals With Rheumatoid Arthritis: A Population-Based Study. J Rheumatol. Published 15 October 2024. doi:10.
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