Comorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis
Authors' conclusion
More than 40% of patients with prevalent RA did not experience worse mortality than their peers without RA. The cluster with the worst prognosis (<10% of patients with prevalent RA) was older, had more comorbidities and had less disease-modifying antirheumatic drug and biological use compared with the other clusters.
Study context
- Population
- Residents of an eight-county region with prevalent rheumatoid arthritis (RA) on 1 January 2015, followed until death, last contact or 31 December 2021 (72% female; 94% white; median age 64 years, median RA duration 7 years)55 comorbidities
- Participants
- 1,643 residents
- Exposure
- Comorbidity clusters compared for RA disease activity and mortality
- Cluster 1n = 686
- Cluster 2n = 200
- Cluster 3n = 623
- Cluster 4n = 134
- Outcome
- Association of comorbidity clusters with RA disease activity and mortality (standardised mortality ratios)
Methodological detailslatent class analysis, standardised mortality ratios
- Latent class analysis
- Standardised mortality ratios
Main finding
As reported in the abstract
Four clusters were identified
4
Observational data: associations, not effects.
Original publication
Comorbidity clusters in patients with rheumatoid arthritis identify a patient phenotype with a favourable prognosis. Ann Rheum Dis. Published 11 April 2024. doi:10.
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