Risk Factors for Dementia in Patients With Incident Rheumatoid Arthritis: A Population-Based Cohort Study
Authors' conclusion
Apart from age, hypertension, depression, and anxiety, all of which are universally recognized risk factors for dementia, clinically active RA and presence of CVD were associated with an elevated risk of dementia incidence among patients with RA.
Study context
- Population
- Residents of 8 counties in Minnesota aged ≥ 50 years meeting 1987 ACR criteria for incident rheumatoid arthritis (RA) between 1980 and 2014, followed until death/migration or December 31, 2019; dementia before RA incidence excluded103 developed dementia
- Participants
- 886 residents
- Outcome
- Incident dementia (2 relevant ICD-9 or ICD-10 codes at least 30 days apart)
Methodological detailsinception cohort
- Inception cohort
Main finding
As reported in the abstract
Risk factors for incident dementia (adjusted for age, sex, calendar year of RA incidence) · median follow-up 8.5 yrs
- Older age at RA incidence, HR per 1 year increase
- 1.14 (95% CI 1.12-1.17)
- Rheumatoid nodules, HR
- 1.76 (95% CI 1.05-2.95)
- Hypertension, HR
- 1.84 (95% CI 1.19-2.85)
- Large joint swelling, HR
- 2.03 (95% CI 1.14-3.60)
- Any cardiovascular/cerebrovascular disease (CVD), HR
- 2.25 (95% CI 1.38-3.66)
- Ischemic stroke, HR
- 3.16 (95% CI 1.84-5.43)
- HF, HR
- 1.82 (95% CI 1.10-3.00)
- Anxiety, HR
- 1.86 (95% CI 1.16-2.97)
- Depression, HR
- 2.63 (95% CI 1.76-3.93)
Observational data: associations, not effects.
Original publication
Risk Factors for Dementia in Patients With Incident Rheumatoid Arthritis: A Population-Based Cohort Study. J Rheumatol. Published 15 July 2022. doi:10.
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