Differences in Cause-Specific Mortality in Patients With Rheumatoid Arthritis by Sex and Seropositivity
Authors' conclusion
Seropositivity in persons with RA associates with a significantly increased risk of death, particularly due to respiratory causes, whereas no increased risk was found in seronegative patients.
Study context
- Population
- Adult residents of Olmsted County, Minnesota, with incident rheumatoid arthritis (RA) 1980–2019 (ACR 1987 criteria) and matched non-RA residents
- Participants
- 1,337 vs 4,011
- Exposure
- Incident RA vs matched non-RA residents
- RAn = 1,337
- Non-RAn = 4,011reference
- Outcome
- All-cause and cause-specific mortality
Methodological detailscommunity population-based inception cohort, matched 3:1 by age and sex, competing risks/cumulative incidence methods, Cox models adjusted for sex, age and calendar year of index
- Community population-based inception cohort
- Matched 3:1 by age and sex
- Competing risks/cumulative incidence methods
- Cox models adjusted for sex, age and calendar year of index
Main finding
As reported in the abstract
Death due to respiratory causes, RA vs non-RA, by serostatus
Each group vs Non-RAAdjusted hazard ratio (95% CI)P value
Seropositive RA
2.26(1.56–3.26)
interaction P < 0.001Seronegative RA
0.52(0.24–1.13)
interaction P < 0.001Observational data: associations, not effects.
Original publication
Differences in Cause-Specific Mortality in Patients With Rheumatoid Arthritis by Sex and Seropositivity. J Rheumatol. Published 15 September 2025. doi:10.
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