Validating the Fracture Risk Assessment Tool Score in a US Population-Based Study of Patients With Rheumatoid Arthritis
Authors' conclusion
The FRAX tool is an accurate method for estimating major osteoporotic and hip fracture risk in patients with RA.
Study context
- Population
- Residents of Olmsted County, Minnesota, with rheumatoid arthritis (RA) (age 40–89 years) and age- and sex-matched non-RA comparators
- Participants
- 662 vs 658
- Exposure
- Observed vs FRAX-predicted 10-year major osteoporotic and hip fractures in RA and non-RA comparators
- RAn = 662
- Non-RAn = 658reference
- Outcome
- Accuracy of FRAX predictions: observed vs predicted major osteoporotic and hip fractures (standardized incidence ratios (SIRs))
- Follow-up
- 10 years
Methodological detailspopulation-based, matched 1:1 on age and sex
- Population-based
- Matched 1:1 on age and sex
Main finding
As reported in the abstract
Observed vs FRAX-predicted fractures in RA · follow-up truncated at 10 years (median 9.0 years)
Major osteoporotic fractures in RA: 76 observed vs 67.0 predicted, SIR
1.13
95% CI 0.91–1.42
Hip fractures in RA: 21 observed vs 23.3 predicted, SIR
0.90
95% CI 0.59–1.38
Observational data: associations, not effects.
Further findings
- The observed and predicted major osteoporotic and hip fracture risks were similar for patients with RA and non-RA comparators
Original publication
Validating the Fracture Risk Assessment Tool Score in a US Population-Based Study of Patients With Rheumatoid Arthritis. J Rheumatol. Published 1 July 2023. doi:10.
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