Revised Swedish FRAX models and the establishment of age-dependent intervention thresholds
Authors' conclusion
The revised FRAX models provide more accurate fracture prediction in Sweden, with lower risk estimates for older people, but due to the introduction of age-dependent intervention thresholds, it is likely that more younger patients will become eligible for treatment in Sweden.
Study context
- Population
- All persons aged ≥40 years living in Sweden between 2005 and 2021
- Exposure
- Revised FRAX models vs previous FRAX model
- Outcome
- Development of a revised FRAX model based on region of birth and updated death and fracture incidences
Methodological detailsnational registries, population-based
- National registries
- Population-based
Main finding
As reported in the abstract
- Revised model yielded lower 10-year probabilities of both hip fracture and major osteoporotic fracture (MOF) in men and women vs previous FRAX model
- Non-Nordic models showed substantially lower probabilities across all age groups and sexes
Observational data: associations, not effects.
Further findings
Age-dependent intervention thresholds for MOF without BMD (10-year probability)
- Age 40 years
- 4.5%
- Age 70 years and older
- 21.5%
Original publication
Revised Swedish FRAX models and the establishment of age-dependent intervention thresholds. Osteoporos Int. Published 23 April 2026. doi:10.
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