Long‐Term Outcomes in Seronegative Rheumatoid Arthritis
Authors' conclusion
After initial diagnosis of seronegative RA, about 13% of individuals had a change in diagnosis and a quarter experienced drug-free remission within 10 years.
Study context
- Population
- Adult residents of Olmsted County, Minnesota, with incident seronegative rheumatoid arthritis (RA), 2005–202368% women
- Participants
- 176 residents
- Outcome
- Cumulative incidence of diagnosis switching, drug-free remission and initiation of a b/tsDMARD
- Follow-up
- 10 years
Methodological detailspopulation-based, manual chart review, competing-risk analysis, Data collected from January 1, 2005, to December 31, 2023
- Population-based
- Manual chart review
- Competing-risk analysis
- Data collected from January 1, 2005, to December 31, 2023
Main finding
As reported in the abstract
10-year cumulative incidence of a change in diagnosis (competing risk of death)
10-year cumulative incidence of a change in diagnosis, 95% CI 8.7%-18.9%
12.8%
Observational data: associations, not effects.
Further findings
Most common change in diagnosis: to spondyloarthritis
- Change in diagnosis to spondyloarthritis
- 4%
10-year cumulative incidence of drug-free remission (competing risks of death or change in diagnosis)
- 10-year cumulative incidence of drug-free remission, 95% CI 20.7%-34.2%
- 26.6%
10-year cumulative incidence of b/tsDMARD initiation (competing risks of death or change in diagnosis)
- 10-year cumulative incidence of b/tsDMARD initiation, 95% CI 14.7%-26.9%
- 19.9%
Individuals entering drug-free remission over median follow-up of 11.8 years
- Individuals who entered drug-free remission
- 49
Original publication
Long‐Term Outcomes in Seronegative Rheumatoid Arthritis. Arthritis Care Res (Hoboken). Published 15 March 2026. doi:10.
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