Autoantibody biomarkers and first-line therapy response in rheumatoid arthritis (RA): findings from the CAP48 cohort
Main finding · Baseline antibody reactivity, not achieving vs achieving LDA (DAS28-CRP/SDAI), total RA cohortResult — go to the resultOdds ratio 3.64 95% CI 1.34–9.91Authors' conclusion
In the CAP48 cohort, the anti-UH-RA antibody panel was associated with a lack of response to first-line therapy for certain clinical measures, observed at 9 months in the total RA cohort and at 6 and 24 months in patients with seronegative status.
Study context
- Population
- Patients with early and naïve RA treated mainly with MTX monotherapy (CAP48 cohort)
- Participants
- 165 baseline samples
- Exposure
- Baseline anti-UH-RA.305/318/329 antibody reactivity in patients not achieving vs achieving low disease activity (LDA)
- Outcome
- Association of baseline anti-UH-RA.305/318/329 antibody reactivity with failure to reach remission or LDA (DAS28-CRP, CDAI/SDAI)
- Follow-up
- 3, 6, 9 and 24 months
Methodological detailsobservational, multivariable analyses
- Observational
- Multivariable analyses
Main finding
As reported in the abstract
Baseline antibody reactivity, not achieving vs achieving LDA (DAS28-CRP/SDAI), total RA cohort · 9 months
Odds ratio
3.64
95% CI 1.34–9.91
P = 0.045
By group
Not achieving LDAvs Achieving LDA
OR 3.64 (95% CI 1.34–9.91); P = 0.045
Observational data: associations, not effects.
Further findings
| Outcome | Not achieving LDA | Achieving LDA | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| Antibody reactivity and not achieving LDA (DAS28-CRP), seronegative RA (subgroup) · 6 months | 42.1% | 12.5% | 5.09 (1.2–27.0) | P = 0.05 | |
| Baseline antibody positivity and not achieving LDA (SDAI), seronegative RA (subgroup) · 24 months | 29.9 (2.5–109.2) | P = 0.01 | |||
| 0.050.21520Odds ratio (log scale) |
Original publication
Autoantibody biomarkers and first-line therapy response in RA: findings from the CAP48 cohort. RMD Open. Published 13 March 2026. doi:10.
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