Prevalence of frailty and pre-frailty in patients with rheumatoid arthritis: a systematic literature review and meta-analysis
Authors' conclusion
(Pre-)frailty is common in RA patients. Large part of the variation is explained by clinical and methodological heterogeneity.
Study context
- Population
- Patients with RA, studies 2001–2021 (weighted average age 58.0 years)25/1,363 studies included
- Outcome
- Prevalence of (pre-)frailty in RA patients
Methodological detailsrandom effects models, conference abstracts included, two independent reviewers
- Random effects models
- Conference abstracts included
- Two independent reviewers
Pooled result
As reported in the abstract
Pooled prevalence (Fried criteria meta-analysis)
Pre-frailty pooled prevalence
52.8%
95% CI 42.7–62.8; I2=99%
Frailty pooled prevalence
24.0%
95% CI 19.4–28.6; I2=96%
Further pooled results
Prevalence ranges across all included studies (systematic literature review (SLR))
- Pre-frailty prevalence range (median 35.8%)
- 20.4%-71%
- Frailty prevalence range (median 23.1%)
- 1.2%-75.1%
Prevalence by age and by instrument
- (Pre-)frailty highly prevalent in all age groups
- Prevalence generally higher with instruments including psychological and social domains vs solely physical domain
Original publication
Prevalence of frailty and pre-frailty in patients with rheumatoid arthritis: a systematic literature review and meta-analysis. Clin Exp Rheumatol. Published 12 July 2022. doi:10.
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