Polygenic risk scores for rheumatoid arthritis and idiopathic pulmonary fibrosis and associations with rheumatoid arthritis (RA), interstitial lung abnormalities, and quantitative interstitial abnormalities among smokers
Authors' conclusion
RA and IPF PRSs were associated with their intended phenotypes among non-Hispanic White participants but performed poorly among Black/African American participants.
Study context
- Population
- Current/former smokers in COPDGene with chest HRCT at enrollment (mean age 59.6 years, 46.4 % female, 67.2 % non-Hispanic White, 32.8 % Black/African American)
- Participants
- 9,230 COPDGene participants
- Exposure
- RA and idiopathic pulmonary fibrosis (IPF) polygenic risk scores (per unit) and associations with RA, interstitial lung abnormalities (ILA) and quantitative CT features
- Outcome
- Associations of RA and IPF polygenic risk scores (PRSs) with RA, ILA and QCT features (non-Hispanic White participants)
Methodological detailsmulticenter, genetic association analysis, multivariable logistic and linear regression
- Multicenter
- Genetic association analysis
- Multivariable logistic and linear regression
Main finding
As reported in the abstract
RA PRS and RA diagnosis: OR per unit
1.32
95% CI 1.18–1.49
IPF PRS and ILA: OR per unit
1.88
95% CI 1.52–2.32
IPF PRS and quantitative interstitial abnormalities: adjusted β per unit (p = 7.3 × 10-8)
+0.50 %
Observational data: associations, not effects.
Further findings
Associations among Black/African American participants
- No statistically significant associations
Original publication
Polygenic risk scores for rheumatoid arthritis and idiopathic pulmonary fibrosis and associations with RA, interstitial lung abnormalities, and quantitative interstitial abnormalities among smokers. Semin Arthritis Rheum. Published 15 March 2025. doi:10.
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