Prevalence and mortality associations of interstitial lung abnormalities in rheumatoid arthritis within a multicentre prospective cohort of smokers
Main finding · ILA prevalenceResult — go to the resultOdds ratio 4.76 95% CI 2.54–8.92Authors' conclusion
In this cohort of smokers, RA was associated with ILAs and this persisted after adjustment for current/past smoking and genetic/lifestyle risk factors.
Study context
- Population
- Current and past smokers in COPDGene with research chest high-resolution CT (HRCT), excluding known interstitial lung disease (ILD) or bronchiectasis
- Participants
- 83 vs 8,725
- Exposure
- RA vs non-RA comparators
- RAn = 83
- Non-RAn = 8,725reference
- Outcome
- Prevalence of interstitial lung abnormalities (ILAs) and all-cause mortality
Methodological detailsmulticentre, multivariable logistic regression, Cox regression
- Multicentre
- Multivariable logistic regression
- Cox regression
Main finding
ILA prevalence
Odds ratio
4.76
95% CI 2.54–8.92
By group
RAvs Non-RA
OR 4.76 (95% CI 2.54–8.92)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| All-cause mortality, RA with ILAs or indeterminate for ILAsRA with ILAs or indeterminatevs Non-RA without ILAs | 3.16 (2.11–4.74) | |
| All-cause mortality, RA with ILAs or indeterminate for ILAsRA with ILAs or indeterminatevs RA without ILA | 3.02 (1.36–6.75) | |
| 0.10.31310Hazard ratio (log scale) |
Original publication
Prevalence and mortality associations of interstitial lung abnormalities in rheumatoid arthritis within a multicentre prospective cohort of smokers. Rheumatology (Oxford). Published 23 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →