Rheumatoid arthritis and changes on spirometry by smoking status in two prospective longitudinal cohorts
Authors' conclusion
Smokers with RA, especially those with baseline obstructive spirometric patterns, experienced lower FEV1% and FEV1/FVC decline than non-RA comparators. Conversely, never smokers with RA had more FEV1% decline than non-RA comparators.
Study context
- Population
- Participants of the UK Biobank and COPDGene with baseline and follow-up spirometry (second visit after 5–7 years)
- Participants
- 233 vs 37,735
- Exposure
- Rheumatoid arthritis (RA) vs non-RA comparators
- RAn = 233
- Non-RAn = 37,735reference
- Outcome
- Annual changes in FEV1% and FVC% (per cent predicted)
- Follow-up
- 5-7 years
Methodological detailstwo prospective longitudinal cohorts (UK Biobank and COPDGene), multivariable linear regression, stratified by baseline smoking status and obstructive pattern (FEV1/FVC <0.7)
- Two prospective longitudinal cohorts (UK Biobank and COPDGene)
- Multivariable linear regression
- Stratified by baseline smoking status and obstructive pattern (FEV1/FVC <0.7)
Main finding
As reported in the abstract
Annual FEV1% change, by smoking status
β
−0.49
P = 0.04
never smokers without obstructive pattern; more FEV1% decline with RA
β
0.50
P = 0.02
ever smokers with ≥10 pack-years; less FEV1% decline with RA
β
1.12
P = 0.01
ever smokers ≥10 pack-years with obstructive pattern at baseline
Observational data: associations, not effects.
Further findings
- Results were similar for FEV1/FVC decline
Original publication
Rheumatoid arthritis and changes on spirometry by smoking status in two prospective longitudinal cohorts. RMD Open. Published 17 June 2024. doi:10.
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