Cytotoxic Response of CD4 + T Cells Orchestrated by SLAMF4 in Rheumatoid Arthritis
Authors' conclusion
This study emphasizes that Cytotox-F4high Tem represent a significant CD4+ CTL subpopulation involved in RA
Study context
- Population
- Peripheral blood (PB) and synovial fluid (SF) mononuclear cells from patients with rheumatoid arthritis (RA)
- Outcome
- CD4+ T cell subpopulations expressing SLAMFs in RA
Methodological detailsflow cytometry, RNA sequencing, high-dimensional unsupervised clustering, pathway enrichment analyses
- Flow cytometry
- RNA sequencing
- High-dimensional unsupervised clustering
- Pathway enrichment analyses
Main finding
As reported in the abstract
- In PB of patients with active RA, SLAMF4+ effector memory CD4+ T cells (Tem) were the only overrepresented SLAMF-expressing CD4+ T cell subpopulation
- Positive correlation between RA activity and SLAMF4+ Tem restricted to those coexpressing SLAM-associated protein (SAP) and CCR5
- SLAMF4+ CCR5+ Tem display a cytotoxicity-related gene signature (GSEA of RNA sequencing)
- Among PB cytotoxic Tem subpopulations, only SLAMF4high SAP+ CCR5+ Tem (Cytotox-F4high Tem) correlated with RA activity
- Cytotox-F4high Tem were the only CD4+ CTL population present in SF of patients with active disease
Original publication
Cytotoxic Response of CD4 + T Cells Orchestrated by SLAMF4 in Rheumatoid Arthritis. Arthritis Rheumatol. Published 10 March 2025. doi:10.
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