Lupus & antiphospholipid syndrome
When is the right time to change therapy? An observational study of the time to response to immunosuppressive drugs in systemic lupus erythematosus
Authors' conclusion
Our findings suggest that clinical improvement of extrarenal flares typically occurs within 6 months of initiating IS.
Study context
- Population
- Patients with SLE with extrarenal flares requiring a change in immunosuppressants, 2015–2022
- Participants
- 81 patients
- Exposure
- Late responders vs Early responders
- Outcome
- Response to immunosuppressants (LLDAS5)
- Follow-up
- 12 months
Methodological detailsCox model analysis, contingency table analysis
- Cox model analysis
- Contingency table analysis
Main finding
As reported in the abstract
Association of IS change with achieving LLDAS5
- Cox model: significant association of a change in immunosuppressants (IS) with achieving lupus low disease activity state (LLDAS5)
- p=0.019
- Significant relationship between IS change at 6 months and achieving LLDAS5 and remission at 12 months
- p=0.004
Observational data: associations, not effects.
Original publication
When is the right time to change therapy? An observational study of the time to response to immunosuppressive drugs in systemic lupus erythematosus. Lupus Sci Med. Published 23 July 2024. doi:10.
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