Lupus & antiphospholipid syndrome
Cardiac involvement in systemic lupus erythematosus: Interest of 2D global longitudinal strain
Authors' conclusion
Cardiac involvement during SLE is a frequent and most often asymptomatic complication.
Study context
- Population
- Patients followed for systemic lupus erythematosus (SLE) at the internal medicine and cardiology department of the HMPIT, May-November 202333 women and seven men
- Participants
- 40 patients
- Exposure
- SLE patients with heart disease vs without heart disease
- Outcome
- Frequency and characteristics of ultrasound abnormalities in lupus patients; benefit of TTE with global longitudinal strain (GLS)
Methodological detailssingle-centre, TTE coupled with 2D-strain in all patients; cardiac involvement defined by ultrasound
- Single-centre
- TTE coupled with 2D-strain in all patients; cardiac involvement defined by ultrasound
Main finding
As reported in the abstract
Cardiac manifestations
Cardiac manifestations reported
60%
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Dyspnea, chest pain and serositisHeart disease vs No heart disease · dyspnea, significantly more frequent | P = 0.02 |
| Dyspnea, chest pain and serositisHeart disease vs No heart disease · chest pain, significantly more frequent | P = 0.03 |
| Dyspnea, chest pain and serositisHeart disease vs No heart disease · serositis, significantly more frequent | P = 0.01 |
| Average GLSHeart disease vs No heart disease · GLS significantly altered in heart disease group | P = 0.01 |
| Frequency of pathological GLSHeart disease vs No heart disease · significantly higher with lupus heart disease | P < 0.01 |
Manifestations in the heart disease group
- Palpitations
- 29%
- Chest pain
- 25%
- Dyspnea
- 67%
- Pericarditis
- 37%
- Pulmonary arterial hypertension (PAH)
- 8%
- Myocarditis
- 12%
Mean left ventricular ejection fraction (LVEF)
- No significant difference between the two groups
Original publication
Cardiac involvement in systemic lupus erythematosus: Interest of 2D global longitudinal strain. Lupus. Published 23 July 2024. doi:10.
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