When does obesity exert its effect in conferring risk of developing rheumatoid arthritis (RA): a large study in cohorts of symptomatic persons at risk
Main finding · Inflammatory arthritis development within CSA, obesity vs normal weight (pooled meta-analysis of four cohorts)Result — go to the resultHazard ratio 1.01 95% CI 0.93–1.08Authors' conclusion
Obesity is not associated with RA development within CSA patients but BMI has already increased in CSA compared to the general population.
Study context
- Population
- Symptomatic persons at risk for RA with clinically suspect arthralgia (CSA) from four cohorts (CSA Leiden, CSA Rotterdam, SONAR and TREAT EARLIER placebo arm)
- Participants
- 1,107 persons4 cohorts
- Exposure
- Obesity vs normal weight within CSA; Body mass index (BMI) at CSA onset vs age-/sex-matched general population
- Outcome
- (1) BMI at CSA onset vs general population; (2) association between BMI and inflammatory arthritis development within CSA
- Follow-up
- 2 years
Methodological detailsfour cohorts, age-matched/sex-matched general population comparison, Cox regression, meta-analysis of cohorts
- Four cohorts
- Age-matched/sex-matched general population comparison
- Cox regression
- Meta-analysis of cohorts
Main finding
As reported in the abstract
Inflammatory arthritis development within CSA, obesity vs normal weight (pooled meta-analysis of four cohorts)
Hazard ratio
1.01
95% CI 0.93–1.08
Obesityvs Normal weight
HR 1.01 (95% CI 0.93–1.08)
Observational data: associations, not effects.
Original publication
When does obesity exert its effect in conferring risk of developing RA: a large study in cohorts of symptomatic persons at risk. RMD Open. Published 12 January 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →