Determination of the factors associated with antigen-specific CD4+ T-cell responses to BNT162b2 in patients with rheumatoid arthritis
Authors' conclusion
Clinical and immunological variables that are associated with antigen-specific CD4 T-cell responses in patients with RA were determined by analysing immune responses against SARS-CoV-2 vaccine.
Study context
- Population
- Patients with rheumatoid arthritis (RA) having received two doses of BNT162b2 (mRNA SARS-CoV-2 vaccine)
- Participants
- 431 patients
- Outcome
- Factors associated with vaccine antigen-specific CD4+ T-cell responses (CD154 expression, intracellular cytokines) and antigen-specific IgG
Methodological detailsmultivariate analysis, unsupervised hierarchical clustering
- Multivariate analysis
- Unsupervised hierarchical clustering
Main finding
As reported in the abstract
Factors associated with anti-vaccine immune responses
- Ageing negatively affects CD4+ T-cell response and antibody production (multivariate analysis)
- No association between presence or levels of RF/anti-CCP and anti-vaccine immune responses
- MTX and prednisolone reduced B cell but not T-cell responses
- Conventional immunophenotyping by chemokine receptor expression not associated with actual CD4+ T-cell response, except for Th1
- Functional immunophenotyping by antigen-specific cytokine profiles stratified patients into three clusters; Th1-dominant type less frequently underwent joint surgery
Observational data: associations, not effects.
Original publication
Determination of the factors associated with antigen-specific CD4+ T-cell responses to BNT162b2 in patients with rheumatoid arthritis. RMD Open. Published 12 January 2024. doi:10.
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