Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity
Authors' conclusion
Disease activity flares were associated with a significant increase in median RAID, supporting its ability to respond to flare.
Study context
- Population
- Patients with RA in sustained remission randomised to continued stable treatment or tapering (ARCTIC REWIND), with flares within 12 months56 flares
- Participants
- 248 patients
- Comparison
- RAID vs PGA, Disease Activity Score (DAS) and C reactive protein (CRP) in discriminating disease activity flares
- Primary endpoint
- Discriminative accuracy (AUC) for disease activity flare (DAS >1.6, DAS increase ≥0.6 and ≥2 swollen joints of 44, or patient and rheumatologist agreed clinically significant flare)
- Follow-up
- 12 months
Methodological detailsROC analyses based on logistic regression models, Wilcoxon signed-rank test
- ROC analyses based on logistic regression models
- Wilcoxon signed-rank test
Primary result
As reported in the abstract
AUC for discriminating flare
RAID
0.88
AUC · 95% CI 0.83–0.93
Patient global assessment
0.92
AUC · 95% CI 0.87–0.97
DAS
0.94
AUC · 95% CI 0.90–0.98
CRP
0.76
AUC · 95% CI 0.69–0.84
Further findings
AUC
RAID pain
0.91(95% CI 0.86–0.95)
RAID sleep
0.69(95% CI 0.59–0.79)
Change at visits related to flare (RAID, PGA, DAS, CRP)
- All changed significantly at the visits related to flare
- P < 0.001
- Wilcoxon signed-rank test
Original publication
Performance of the Rheumatoid Arthritis Impact of Disease (RAID) score in relation to flares in disease activity. RMD Open. Published 12 January 2024. doi:10.
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