Lupus & antiphospholipid syndrome
VO 2 on-kinetics and aerobic exercise training in females with systemic lupus erythematosus
Main finding · VO2 on-kineticsResult — go to the resultMean difference −12.0 s 95% CI −18.1 to −6.0Authors' conclusion
Following supervised exercise training, females with SLE demonstrated faster VO2 on-kinetics, which were also related to cardiorespiratory fitness.
Study context
- Population
- Females with systemic lupus erythematosus (SLE) (SELENA-SLEDAI ≤ 4), 42 ± 10 years[HHb]/VO2 ratio subset n = 10
- Participants
- 16 females
- Comparison
- Before vs after 12 weeks of supervised aerobic exercise training
- After aerobic exercise training (AET)n = 16
- Before AETn = 16reference
- Outcome
- VO2 on-kinetics
- Follow-up
- 12 weeks
Methodological detailssupervised vigorous treadmill aerobic exercise training for 12 weeks, paired sample t-tests or Wilcoxon signed-rank tests
- Supervised vigorous treadmill aerobic exercise training for 12 weeks
- Paired sample t-tests or Wilcoxon signed-rank tests
Main finding
As reported in the abstract
Mean difference
−12.0 s
95% CI −18.1 to −6.0
P < 0.001
Post-AETvs Pre-AET
mean difference −12.0 s (95% CI −18.1 to −6.0); P < 0.001
Further findings
| Outcome | Median difference (s) (95% CI) | P value | |
|---|---|---|---|
| HR on-kinetics · 12 weeksPost-AETvs Pre-AETFaster following AET | −6.7 (−30.8 to −1.2) | P = 0.022 | |
| [HHb] time course (gastrocnemius deoxygenation) · 12 weeksPost-AETvs Pre-AETChange unlikely | −1.1 (−3.6 to 23.5) | P = 0.508 | |
| −40−2002040Difference, s (linear scale) |
Correlation of post-AET VO2 time constant with cardiorespiratory fitness (Spearman)
- Peak VO2: rs = −0.562, p = .024
- Peak work rate: rs = −0.535, p = .033
Original publication
VO 2 on-kinetics and aerobic exercise training in females with systemic lupus erythematosus. Lupus. Published 12 June 2025. doi:10.
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