Vaccination against COVID-19 reduced the mortality risk of COVID-positive hip fracture patients to baseline levels: the nationwide data-linked IMPACT Protect study
Authors' conclusion
Vaccination was associated with lower COVID-19 infection risk. Vaccinated COVID-positive patients had a similar mortality risk to COVID-negative patients, suggesting a reduced severity of infection.
Study context
- Population
- Patients aged > 50 years with hip fracture in Scotland, 01/03/20–31/12/21 (median age 82.0 years; 69.9% female)606 COVID-positive within 30 days
- Participants
- 13,345 patients
- Exposure
- Vaccinated vs unvaccinated hip fracture patients; COVID-positive vs COVID-negative
- Outcome
- 30-day mortality; COVID-19 within 30 days of fracture
- Follow-up
- 30 days
Methodological detailsnationwide, data-linked, multivariable logistic regression
- Nationwide
- Data-linked
- Multivariable logistic regression
Main finding
As reported in the abstract
30-day mortality (adjusted)
Each group vs COVID-negativeOdds ratio (CI)P value
Unvaccinated COVID-positive
2.77(2.12–3.62)
P < 0.001Vaccinated COVID-positive
0.93(0.53–1.60)
P = 0.783Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| COVID-positive within 30 days of fracture, vaccinatedvs unvaccinatedMultivariable logistic regression | 0.41 (0.34–0.48) | P < 0.001 | |
| 0.20.5125Odds ratio (log scale) |
| Outcome | COVID-negative | P value |
|---|---|---|
| 30-day mortality, COVID-positive vs COVID-negative (unadjusted) | 7.9% | P < 0.001 |
- 30-day mortality, COVID-positive vs COVID-negative (unadjusted): COVID-positive 15.8%
Original publication
Vaccination against COVID-19 reduced the mortality risk of COVID-positive hip fracture patients to baseline levels: the nationwide data-linked IMPACT Protect study. Osteoporos Int. Published 28 October 2023. doi:10.
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