Osteoporotic Fracture, Diagnostic Activity, and Treatment in Patients With Gout
Authors' conclusion
Patients with gout experienced greater rates of osteoporotic fracture and greater osteoporotic fracture risk factors (eg, chronic kidney disease and greater glucocorticoid use) compared to patients with OA and STR yet were less likely to receive bone protective therapies.
Study context
- Population
- Patients with gout and matched comparators with osteoarthritis (OA) and soft tissue rheumatism (STR), ACR RISE registry linked to Medicare claims (2015–2021)
- Exposure
- Gout vs matched OA and vs matched soft tissue rheumatism
- Outcome
- Osteoporotic fractures (crude and adjusted incidence rates (IRs) and IR ratios (IRRs))
Methodological details1:1 exact matching (age ±2 years, sex, race, enrollment quarter), RISE registry linked to Medicare claims
- 1:1 exact matching (age ±2 years, sex, race, enrollment quarter)
- RISE registry linked to Medicare claims
Main finding
As reported in the abstract
Nonvertebral osteoporotic fracture rates
Incidence rate ratio (95% CI)
Goutvs OA
1.4(1.1–1.8)
Goutvs STR
2.0(1.3–3.1)
Observational data: associations, not effects.
Further findings
Bone protective therapy use during follow-up
| Outcome | Gout | OA | STR |
|---|---|---|---|
| Bone protective therapy use at baseline (gout vs OA matched cohort) | 5% | 11.8% | — not stated in the abstract |
| Baseline osteoporotic fracture / osteoporosis diagnosis prevalence (gout vs OA matched cohort)Value = osteoporotic fracture prevalence | 1.4% | 2.6% | |
| Osteoporosis diagnosis prevalence | 7.1% | 15.4% | — not stated in the abstract |
| Bone protective therapy use at baseline (gout vs STR matched cohort)Approximately | 9.0% | — not stated in the abstract | 23.2% |
— not stated in the abstract
- Bone protective therapy use during follow-up: Gout 3.4%
- Bone protective therapy use during follow-up: Gout 2.0% vs OA 4.5%; Gout 3.4% vs STR 10.3% (separate matched cohorts)
Original publication
Osteoporotic Fracture, Diagnostic Activity, and Treatment in Patients With Gout. Arthritis Care Res (Hoboken). Published 10 August 2026. doi:10.
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