Excess subsequent fracture and mortality risk after ankle fractures: a relative survival analysis of the 45 and Up Study
Authors' conclusion
In the 45 and Up cohort, there was a modest but significant increased risk of fracture following ankle fracture seen in both women and men. In men, but not women, ankle fractures were associated with 10% excess mortality.
Study context
- Population
- 45 and Up Study, NSW, Australia, 2006 to 2017; baseline questionnaire linked to ED, admitted-patient and death registry data1,490,651 person-years
- Participants
- 143,070 vs 123,818
- Exposure
- Ankle fracture vs overall cohort
- Womenn = 143,070
- Menn = 123,818
- Outcome
- Excess risk of subsequent fracture and mortality following ankle fractures
- Follow-up
- 5 years
Methodological detailspopulation-based, relative survival analysis, linked administrative data
- Population-based
- Relative survival analysis
- Linked administrative data
Main finding
As reported in the abstract
Excess risk of subsequent fracture after ankle fracture, vs risk of incident fracture in the study
Excess risk of subsequent fracture, both women and men
5%
95% CI 3–8%
Observational data: associations, not effects.
Further findings
Cumulative excess mortality after ankle fracture, vs overall cohort · 5 years
- Men
- 10% (95% CI 6-13%)
- Women: no excess mortality
- 78 deaths in women and 76 deaths in men
Characteristics of participants with ankle fractures who died
- Older
- P < 0.001
- More likely to have had a second fracture
- P < 0.001
- Prior fracture
- P < 0.001
- More comorbidities
- P < 0.001
Original publication
Excess subsequent fracture and mortality risk after ankle fractures: a relative survival analysis of the 45 and Up Study. Osteoporos Int. Published 10 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →