Effect of calcifediol and cholecalciferol on muscle function in postmenopausal women: a randomized controlled trial
Authors' conclusion
Our findings do not support supplementation with daily calcifediol or equivalent high-dose daily vitamin D3 for improving or maintaining lower extremity function among younger postmenopausal women (age 50-70) with osteopenia or osteoporosis, who were pre-selected for vitamin D insufficiency or deficiency (25(OH)D < 30 ng/mL; baseline mean 25(OH)D 23.4 ng/mL).
Study context
- Population
- Postmenopausal women aged 50–70 years with serum 25(OH)D < 30 ng/mL and a DXA-based diagnosis of osteopenia or osteoporosisall but one completed follow-up
- Participants
- 152 women
- Comparison
- Calcifediol 20 µg/day vs vitamin D3 3200 IU/day vs placebo
- Primary endpoint
- Probability of success (improvement or maintenance from baseline) in any of eight lower extremity function tests (gait speed, knee flexor and extensor strength, repeated sit-to-stand; each at 3 and 6 months)
- Follow-up
- 3 and 6 months
Methodological details3-arm, double-blind
- 3-arm
- Double-blind
Primary result
As reported in the abstract
Adjusted probability of success in any of the eight tests
Original publication
Effect of calcifediol and cholecalciferol on muscle function in postmenopausal women: a randomized controlled trial. Osteoporos Int. Published 9 April 2025. doi:10.
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