Twelve-month resistance and impact exercise program or risedronate provides a relative benefit to hip bone structure in postmenopausal women: results from a randomized controlled trial
Authors' conclusion
Exercise and bisphosphonates may influence structural and strength estimates at the hip, but not at peripheral sites (tibia). Neither exercise nor bisphosphonates were found to be superior in improving estimates of hip bone strength.
Study context
- Population
- Postmenopausal women with low bone mass within 6 years of menopause (mean age 54.5 years)
- Participants
- 276 women
- Comparison
- 12-month exercise vs risedronate vs control
- Exercisen = 92
- Risedronaten = 91
- Controln = 93reference
- Primary endpoint
- Changes in tibial bone strength (pQCT) and hip structure analysis (HSA) outcomes from DXA
- Follow-up
- 12 months
Methodological detailsthree-arm
- Three-arm
Primary result
As reported in the abstract
Change in pQCT outcomes (volumetric BMD, area, strength estimates) and HSA measures
Estimate (95% CI)P value
Exercisevs Control
mean percent difference (intertrochanteric cross-sectional area) 2.25 %(0.28–4.12)
P = 0.03Exercisevs Control
mean percent difference (intertrochanteric CSMI) 5.67 %(1.47–9.87)
P < 0.01Exercisevs Control
mean percent difference (intertrochanteric SM) 4.38 %(1.02–7.74)
P = 0.01Exercisevs Control
mean percent difference (narrow neck average cortical thickness) 2.37 %(−0.08 to 4.83)
P = 0.031Risedronatevs Control
mean percent difference (intertrochanteric CSMI) 4.28 %(−0.24 to 8.81)
P = 0.03Between Risedronate and Control
mean percent difference (intertrochanteric SM) 3.35 %(−0.21 to 6.91)
P = 0.03Risedronatevs Control
mean percent difference (shaft subperiosteal width) 0.82 %(0.05–1.58)
P = 0.047Risedronatevs Control
mean percent difference (shaft CSMI) 2.53 %(0.88–4.18)
P = 0.004Risedronatevs Control
mean percent difference (shaft SM) 1.57 %(0.34–2.8)
P = 0.008Exercisevs Control
mean percent difference (neck-shaft angle) 1.27 %(0.13–2.41)
P = 0.04Exercisevs Risedronate
mean percent difference (neck-shaft angle) 1.31 %(0.23–2.39)
P = 0.03Original publication
Twelve-month resistance and impact exercise program or risedronate provides a relative benefit to hip bone structure in postmenopausal women: results from a randomized controlled trial. Osteoporos Int. Published 17 February 2024. doi:10.
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