Spondyloarthritis & psoriatic arthritis
Unveiling the distinctive ossification patterns of diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis using computed tomography three-dimensional reconstruction
Authors' conclusion
Morphological features of osteophytes are helpful to distinguish DISH with AS. Aortic pulsations inhibit or hinder new bone formation in both DISH and AS.
Study context
- Population
- Patients with DISH and matched patients with AS undergoing CTmatched
- Participants
- 50 vs 50
- Comparison
- DISH vs AS
- DISHn = 50
- ASn = 50reference
- Outcome
- Volume, angle and location (contralateral, ipsilateral, bilateral) of osteophytes in each vertebral osteophytes unit (VOU)
Methodological detailsage-, sex-, CT examination site-matched, CT three-dimensional reconstruction
- Age-, sex-, CT examination site-matched
- CT three-dimensional reconstruction
Main finding
As reported in the abstract
Best osteophyte volume cutoff predicting DISH
0.59 cm³
Best osteophyte angle cutoff predicting DISH
40.15°
Observational data: associations, not effects.
Further findings
Osteophyte location (contralateral, bilateral, ipsilateral), % of assessed VOUs
P < 0.001
Contralateral
Bilateral
Ipsilateral
| Outcome | DISH | AS |
|---|---|---|
| Ipsilateral osteophyte volume vs distance from vertebral body centre to descending aorta centre (correlation)Inversely correlated | −0.45 | −0.83 |
| P | P = 0.01 | P < 0.001 |
Factors associated with osteophyte and syndesmophyte progression
- Advanced age, disease duration, smoking and overweight contribute to progression
Original publication
Unveiling the distinctive ossification patterns of diffuse idiopathic skeletal hyperostosis and ankylosing spondylitis using computed tomography three-dimensional reconstruction. Rheumatology (Oxford). Published 22 March 2024. doi:10.
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