Spondyloarthritis & psoriatic arthritis
Impact of body composition on clinical outcomes in patients with active radiographic axial spondyloarthritis under biological therapy
Authors' conclusion
Higher levels of body fat and VAT were positively associated with increased disease activity, functional disability, and reduced spinal mobility in patients with radiographic axSpA treated with bDMARDs.
Study context
- Population
- Patients with AS (radiographic axSpA), candidates for bDMARD therapy with high disease activity despite previous NSAID treatment; mean age 36.5 years, disease duration 6.2 years, Axial Spondyloarthritis Disease Activity Score (ASDAS) 3.4 at baseline
- Participants
- 74 patients
- Outcome
- Association of body composition (bioimpedance analysis (BIA)) with disease activity, physical function and mobility
- Follow-up
- 1 year
Methodological detailsextension of the German Spondyloarthritis Inception Cohort (GESPIC), longitudinal generalized estimating equations, body composition (BC) and outcomes assessed at baseline and every 6 months
- Extension of the German Spondyloarthritis Inception Cohort (GESPIC)
- Longitudinal generalized estimating equations
- BC and outcomes assessed at baseline and every 6 months
Main finding
As reported in the abstract
Association of BC parameters with outcomes over 1 year
- Fat mass value and ASDAS, ß
- 0.012 [−0.003, 0.027] (95% CI)
- Fat mass index and ASDAS, ß
- 0.035 [−0.010, 0.081] (95% CI)
- Fat mass value and BASFI, ß
- 0.037 [0.004, 0.070] (95% CI)
- Fat mass index and BASFI, ß
- 0.125 [0.031, 0.219] (95% CI)
- Visceral adipose tissue (VAT) and reduced spine mobility (BASMI), ß
- 0.20 [0.07, 0.33] (95% CI)
Observational data: associations, not effects.
Further findings
Sex subgroups
- Increase in VAT and fat mass parameters linked to worse disease activity and functional disability in women
- Increase in VAT and fat mass parameters strongly associated with reduced spinal mobility in men
Original publication
Impact of body composition on clinical outcomes in patients with active radiographic axial spondyloarthritis under biological therapy. Rheumatology (Oxford). Published 20 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →