Spondyloarthritis & psoriatic arthritis
16s RNA-based metagenomics reveal previously unreported gut microbiota associated with reactive arthritis and undifferentiated peripheral spondyloarthritis
Authors' conclusion
The microbiota of classical gut-associated ReA and upSpA is similar. Patients have higher diversities in their gut microbiota compared with healthy controls. Both known and previously unreported species associated with ReA/upSpA were identified.
Study context
- Population
- Patients with reactive arthritis (ReA) or undifferentiated peripheral spondyloarthritis (UpSpA) presenting within 4 weeks of onset of the current episode of arthritis, and healthy controls55 patients
- Participants
- 20 / 35 / 36
- Comparison
- Patients with ReA or UpSpA vs healthy controls
- ReAn = 20
- UpSpAn = 35
- Controlsn = 36reference
- Outcome
- Gut microbiota associated with the development of ReA
Methodological details16S rRNA metagenomics, age- and sex-similar controls
- 16S rRNA metagenomics
- Age- and sex-similar controls
Main finding
As reported in the abstract
Gut microbiota (16S rRNA)
Families overexpressed in patients
6
Families overexpressed in controls
5
Genera significantly different between patients and controls
16
Species significantly different between patients and controls
18
Observational data: associations, not effects.
Original publication
16s RNA-based metagenomics reveal previously unreported gut microbiota associated with reactive arthritis and undifferentiated peripheral spondyloarthritis. Rheumatology (Oxford). Published 15 March 2024. doi:10.
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