Spondyloarthritis & psoriatic arthritis
Characterisation of gut microbiota composition in patients with axial spondyloarthritis and its modulation by TNF inhibitor treatment
Authors' conclusion
Several SpA patients' characteristics modulate the composition of gut microbiota as did TNFi treatment. Moreover, the abundance/prevalence of seven OTUs at baseline may be used as a novel non-invasive index that predicts the response to TNFi with greater accuracy than HLA-B27 status, CRP level and measures of disease activity.
Study context
- Population
- Patients with axSpA (ASAS criteria) with active disease despite NSAID intake, eligible for TNF inhibitor (TNFi); baseline mean ASDAS 2.9±1, mean C reactive protein (CRP) 9.7±11.4 mg/L
- Participants
- 61 patients
- Outcome
- Association of gut microbiota composition with patient characteristics and with response to TNFi
Methodological details16S rRNA gene sequencing of stool samples at M0 and M3
- 16S rRNA gene sequencing of stool samples at M0 and M3
Main finding
As reported in the abstract
Gut microbiota composition
- Prevalence/abundance of seven bacterial operational taxonomic units (OTUs) at M0 associated with response to TNFi: genus Sutterella (present only in non-responders) and six in the class Clostridia
- 7
Observational data: associations, not effects.
Original publication
Characterisation of gut microbiota composition in patients with axial spondyloarthritis and its modulation by TNF inhibitor treatment. RMD Open. Published 24 March 2023. doi:10.
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