Spondyloarthritis & psoriatic arthritis
Clinical Significance of Gut Microbiota Community Types for Long‐Term Response to Fecal Microbiota Transplantation in Patients With Psoriatic Arthritis
Authors' conclusion
Recipients with a Bacteroides-dominated community structure were more likely to achieve long-term beneficial response following one FMT.
Study context
- Population
- Patients with moderate-to-high PsA disease activity receiving fecal microbiota transplantation (FMT) as a supplement to MTX, and four FMT donors13 in per-protocol (PP) population
- Participants
- 31 patients
- Comparison
- B-type vs P-type gut microbiota community type in FMT recipients
- B-typen = 17
- P-typen = 14reference
- Primary endpoint
- Long-term clinical beneficial response to FMT
- Follow-up
- Week 26
Methodological detailsshotgun metagenomics, per-protocol population, 15 patients received one single-donor FMT, Stool samples collected before and after FMT (week 4, 12, and 26)
- Shotgun metagenomics
- Per-protocol population
- 15 patients received one single-donor FMT
- Stool samples collected before and after FMT (week 4, 12, and 26)
Primary result
As reported in the abstract
Long-term clinical beneficial response (PP population)
| Group | Value | Patients in PP population |
|---|---|---|
| B-type | 5 events | 7 |
| P-type | 0 events | 6 |
Value
B-type5 events
P-type0 events
Patients in PP population
B-type7
P-type6
- B-type vs P-type: P = 0.021
Further findings
- Persisting engrafted donor strains · week 26 — B-type
- 18 events
- Baseline species diversity · significantly higher in B-type
- P = 0.005
- Persisting engrafted donor strains: 18 engrafted strains
Baseline species diversity
- No difference in disease activity or demographics between B- and P-type
Bacterial strain richness, baseline to week 4 and week 26
- Increased significantly in B-type
- P = 0.016
- Not increased in P-type
Persisting engrafted donor strains · week 26
- Persisted only in B-type recipients, including a Bacteroides clarus strain with negative effect size regarding arthritis pain and patients' global assessment
Original publication
Clinical Significance of Gut Microbiota Community Types for Long‐Term Response to Fecal Microbiota Transplantation in Patients With Psoriatic Arthritis. Arthritis Rheumatol. Published 27 November 2025. doi:10.
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