Spondyloarthritis & psoriatic arthritis
Spinal mobility and functional limitations in patients with diffuse idiopathic skeletal hyperostosis compared to healthy controls and patients with axial spondyloarthritis
Authors' conclusion
DISH is associated with substantial impairments in spinal mobility and physical performance compared with HC. While limitations were comparable to axSpA, the restriction pattern differed, with DISH showing less deficits in rotational movement.
Study context
- Population
- Consecutive patients with diffuse idiopathic skeletal hyperostosis (DISH) or axial spondyloarthritis (axSpA) and healthy controls (HCs)
- Participants
- 50 / 30 / 20
- Exposure
- DISH vs HCs and vs axSpA
- DISHn = 50
- axSpAn = 30
- HCn = 20reference
- Outcome
- Spinal mobility and functional limitations (Bath Ankylosing Spondylitis Metrology Index (BASMI), Short Physical Performance Battery (SPPB), ASPI, electronic ROM and ROK with the Epionics SPINE)
Methodological detailsconsecutive patients, age-adjusted analyses
- Consecutive patients
- Age-adjusted analyses
Main finding
As reported in the abstract
BASMI
DISH
4.6
± 1.0
HC
2.8
± 0.6
axSpA
5.1
± 1.9
DISH vs HC: P < 0.001 · DISH vs axSpA: P = 0.13
Observational data: associations, not effects.
Further findings
| Outcome | DISH | axSpA | HC | P value |
|---|---|---|---|---|
| SPPBDISH vs HC · significantly worse in DISH | 10.2 ± 2.0 | 9.5 ± 1.3 | 11.9 ± 0.4 | P < 0.001 |
| SPPBDISH vs axSpA · comparable | P = 0.08 | |||
| ASPIDISH vs HC · significantly worse in DISH | 46.5 ± 26.1 s | 47.4 ± 23.9 | 20.3 ± 5.3 | P < 0.001 |
| ASPIDISH vs axSpA · comparable | P = 0.91 |
Range of motion (ROM) and range of kinematics (ROK) measures
- DISH vs HC: broad restrictions across ROM and ROK measures (all p<0.001)
- DISH vs axSpA: DISH performed better in rotation to both sides and hip-related measures
- Age-adjusted analyses confirmed similar group differences independent of age
Original publication
Spinal mobility and functional limitations in patients with diffuse idiopathic skeletal hyperostosis compared to healthy controls and patients with axial spondyloarthritis. RMD Open. Published 10 April 2026. doi:10.
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